Background on the tuftsin tetrapeptide (Thr-Lys-Pro-Arg) and the elongated synthetic analogue Selank (TKPRPGP). Animal-model literature, GABAergic-pathway characterizations, and the proteolytic-stability modifications described in published synthesis work.
Selank is a synthetic heptapeptide derived from tuftsin — the natural tetrapeptide Thr-Lys-Pro-Arg released from the heavy chain of immunoglobulin G — extended at the C-terminus by a Pro-Gly-Pro segment to resist enzymatic degradation. Its structure preserves the immunomodulatory motif of native tuftsin while substantially extending plasma stability.
Published preclinical studies report effects on the GABAergic system at the gene-expression level, increases in hippocampal and prefrontal-cortex BDNF in animal-model contexts, and behavioural endpoints in rodent models of generalized anxiety, depression, and morphine withdrawal. The citations below are entry points into that literature.
Disclaimer · Citations are provided as reference material from the published research literature. Strata sells research compounds for laboratory use only and does not interpret, recommend, or extrapolate findings to human application.