Reference reading on nicotinamide adenine dinucleotide and its precursors (NMN, NR), the salvage and de novo biosynthesis pathways, and published in-vitro and animal-model investigations of NAD+ metabolism, sirtuin activation, and age-related decline.
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme central to redox biology and a substrate for multiple enzyme classes including the sirtuin deacetylases, poly(ADP-ribose) polymerases (PARPs), and CD38/CD157. Tissue and cellular NAD+ concentrations decline with chronological age in published rodent and human data, motivating substantial research interest in supplementation with biosynthetic precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).
The literature surveyed below covers NAD+ biosynthesis pathways, the NAD-sirtuin axis in age-related processes, and recent reviews of NMN safety and biomarker investigations. These are entry points to a fast-moving research field; a more focused bibliography by sub-topic (NAD+ synthesis enzymology, sirtuin biology, NMN/NR metabolism) is available on request.
Disclaimer · Citations are provided as reference material from the published research literature. Strata sells research compounds for laboratory use only and does not interpret, recommend, or extrapolate findings to human application.