Literature on the 16-amino-acid MOTS-C, encoded within the 12S rRNA mitochondrial open reading frame. Published metabolic and biochemical characterizations, AMPK-pathway notes, and synthesis methodology references.
MOTS-c is a 16-amino-acid peptide encoded within the MT-RNR1 (12S rRNA) region of the mitochondrial genome — one of the first characterized members of the mitochondrial-derived peptide (MDP) class. The 2015 discovery paper by Lee and colleagues described its translation, tissue distribution, and effects on insulin sensitivity in mouse models.
Subsequent literature describes MOTS-c's interaction with the AMPK signalling pathway, nuclear translocation under metabolic stress, and observations that circulating MOTS-c levels decline with chronological age in published cohort data. The references below are entry points into that body of work, including methodology papers on detection of MOTS-c in plasma for doping control.
Disclaimer · Citations are provided as reference material from the published research literature. Strata sells research compounds for laboratory use only and does not interpret, recommend, or extrapolate findings to human application.